During experiments on the axons of the Woods Hole squid (loligo pealei), we tested our cockroach leg stimulus protocol on the squid's chromatophores.

 

 The results were both interesting and beautiful. The video is a view through an 8x microscope zoomed in on the dorsal side of the caudal fin of the squid. We used a suction electrode to stimulate the fin nerve. Chromatophores are pigmeted cells that come in 3 colors: Brown, Red, and Yellow. Each chromatophore is lined with up to 16 muscles that contract to reveal their color.

Paloma T. Gonzalez-Bellido of Roger Hanlon's Lab in the Marine Resource Center of the Marine Biological Labs helped us with the preparation. You can read their latest paper at:http://rspb.royalsocietypublishing.org/content/early/2012/08/13/rspb.2012.1374

STAR WARS DETOURS™ Trailer

The nine people believed injured by stray police gunfire outside the Empire State Building were not the first to learn how dangerous a crowded street can be in a gunfight.

 Civilians occasionally find themselves in harm's way when officers use deadly force, though usually only a handful of times annually. When that happens, a rigid process of investigation is set in motion — and the police department can reasonably expect a lawsuit. The latest episode came when police say a man disgruntled over losing his job a year ago shot a former colleague to death and pointed his weapon at two police officers in the shadow of a major tourist attraction. He apparently wasn't able to fire before police killed him, one firing off seven rounds and the other nine. Bystanders suffered graze wounds, and some were struck by concrete gouged from buildings by the bullets, authorities said. At least one person said he was actually hit by a bullet. Robert Asika, a 23-year-old tour guide who was hit in the right arm, said he was "100 percent positive" he was shot by a police officer. A witness told police that laid-off clothing designer Jeffrey Johnson fired at officers, but ballistics evidence so far contradicts that, authorities said.

Tracking a Rare Tattoo-Related Infection

A Trail of Ink: Tracking a Rare Tattoo-Related Infection

An uncommon skin infection led to a doctor's investigation into tainted tattoo ink. (Monroe County Health Department)

The reddish-purple rash, seemingly woven into the tattoo on a 20-year-old New Yorker's forearm, was strange enough to have doctors scratching their heads.

This trail began when the man received a tattoo in Rochester, N.Y. in October 2011. A short while later, he noticed the raised, bumpy rash. He called his primary care physician.

Doctors initially treated the man's arm with topical steroids, thinking that the rash was allergic-contact dermatitis. But that only made the problem worse.

By the time dermatologist Dr. Mark Goldgeier saw the patient, it was clear that this was no simple allergy.

He performed a skin biopsy so he could take a closer look at the rash under a microscope. What he saw was startling: the sample was riddled with a wormlike bacterium related to tuberculosis.

"I explained [to the patient] that he had TB, and he had a look of horror on his face," Goldgeier said.

For the patient, the finding meant a trip to an infectious disease specialist to start up to a full year of treatment.

Goldgeier, meanwhile, called the Monroe County Health Department.

"As soon as biopsy came back," he said, "I knew something in the process of tattooing was involved -- the ink, the water used for dilution, the syringes, the dressings."

And so began a nationwide medical mystery.

An article published Wednesday in the New England Journal of Medicine describes how this one dermatologist helped connect the dots in an outbreak of tattoo-related atypical skin infections.

Dr. Byron Kennedy, public health specialist at Monroe County Department of Public Health, took over the case from Goldgeier. Kennedy first confirmed the results by repeating a skin biopsy on the patient. Once again, tendrils of mycobacterium chelonae, a type of tuberculosis-related skin bacteria, showed up in the sample.

Mycobacterium chelonae is a rapidly growing bug found in soil, dust, water, animals, hospitals, and contaminated pharmaceuticals. This family of bacteria does not commonly affect healthy individuals, but in patients with suppressed immune systems -- like those with HIV or on chemotherapy -- these bacteria can cause serious disease, often resulting in death.

The finding sent Kennedy and his associates to the tattoo parlor where the patient had been inked. Everything in the clinic was sterile, which made it unlikely that the infection had arisen there. But the tattoo artist, they learned, had been using a new gray premixed ink purchased in Arizona in April 2011; he used the ink between May and December 2011.

The ingredients of the ink -- pigment, witch hazel, glycerin, and distilled water -- seemed innocuous enough. But further examination revealed that the distilled water in the pigment was the likely culprit of the contamination.

The finding raised a number of questions -- not the least of which was how the bottles of premixed ink passed U.S. Food and Drug Administration regulations.

The U.S. Centers for Disease Control and Prevention acknowledged this gap in regulations Wednesday in its Morbidity and Mortality Weekly report.

"Under the Federal Food, Drug, and Cosmetic Act, tattoo inks are considered to be cosmetics, and the pigments used in the inks are color additives requiring premarket approval," the report says.

Leonardo da Vinci's "The Last Supper" may include two self-portraits of the legendary Renaissance artist, according to a British art expert.

Could both of these "Last Supper" figures be da Vinci self-portraits? (Original image, Wikicommons)Leonardo da Vinci's "The Last Supper" may include two self-portraits of the legendary Renaissance artist, according to a British art expert.

Ross King says the nose, beards and hairstyles of two of the apostles standing to the right of Jesus in the portrait, Thomas and James the Lesser, match a portrait of Leonardo that was made several years after he created his masterpiece.

King told the Independent that while historians have long-suspected Leonardo placed images of himself in his works, no one has thoroughly researched "The Last Supper" for such evidence.

The 15-x-29-foot painting has been the source of endless speculation, though most of the analysis has focused on hidden meanings within the painting itself, such as how each of the apostles is reacting to the revelation that one of them has betrayed Jesus.

Still, King concedes that there is no definitive record of Leonardo's physical appearance but says the Greek physical characteristics were "rarities for an Italian man of that period," according to UPI.

Leonardo da Vinci scholar Charles Nicholl supports King's hypothesis, telling the Independent,"Of all the apostles that [Leonardo] would wish to be identified with, I think Doubting Thomas would be top of his list because Leonardo was a great believer in asking questions rather than accepting what people tell you."

London's secret music venue and their livestream act

With an invite-only door policy and super secret location, Boiler Room is London's most exclusive music venue. But elitism isn't the premise for its clandestine nature—in fact, anyone with an Internet connection can easily join in the fun. Using a simple webcam, the crew behind Boiler Room livestreams each set for the world to see free of charge, and each month more than a million viewers tune in to see performances by artists like James Blake, The xx, Roots Manuva, Neon Indian, Juan Maclean and more.

We recently chilled out to the smooth sounds of Brooklyn's How To Dress Well before rocking out to revered musician Matthew Dear, who brought down the house with an intense 40-minute DJ set. Keep an eye out for our interview with Dear, but for now you can get a little more insight into the underground music scene's most talked about livestream show by checking out our interview with assistant musical programmer and Boiler Room host Nic Tasker.

How important is it for Boiler Room to remain secret, at least in its location?

That is quite an important aspect of it, purely because it means when you do shows you don't get a lot of groupies, pretty much everyone in the room is either a friend of ours or one of the artist's. It helps to create a more relaxed atmosphere for the artist and I think they feel less pressure. They're also just able to chill out and be themselves more rather than having people being like, "Hi can I get your autograph?" If the artists are relaxed usually you get the best music.

It seems like there is more interaction among the crowd than at a typical venue, is that intentional?

It's definitely a social place. All the people that come down, most of them we know and they're all our friends. So they come down, hang, have a drink and just chill out, basically. From our very set-up, we do it with a webcam, we're not a highly professional organization but I think that's kind of the charm of it. The main thing is people come down with the right attitude.

How much of the show is prescribed?

I guess that depends on the artist. We never say anything. Literally, whatever they want to do—we're kind of the platform for them to do whatever they want, so if Matthew Dear wants to come and play an hour of noise with no beats, he can do that. That's fine with us, and I think that's why artists like coming to play for us. We're not like a club where you have to make people dance, we don't give a shit if people dance. It's nice if they do and it makes it more fun, but some nights you just get people appreciating the music, which is equally fun.

Is there a particular kind of artist you guys look for and ask to come perform?

No, not particularly, it's just whatever we're feeling. Thristian [Boiler Room's co-founder] has the main say on musical direction, but it's a massive team effort. In London there's five of us, New York there's two, LA there's one and Berlin there's two.

Tonight you had different set-ups for each artist, do you tailor their positioning in the room to their style?

It definitely depends on the act and what kind of music they do. With live bands we found what works nicely is having them opposite each other because it's like they're in rehearsal, like they're just jamming. Which is again trying to give them that chilled out feel that they're just at home jamming and there happens to be a camera there. For some of our shows we've had over 100,000 viewers. When you think of those numbers it's quite scary, but when you're in the room and it's all friends it creates that vibe that people don't mind. You can imagine if you had all those people in front of you it would be a very different situation.

Have you ever thought of Boiler Room as an East London version of Soul Train?

It's never crossed my mind like that, but I can see why you think that. I like to think of us as the new music broadcaster, kind of the new MTV, but obviously we operate in the underground scene mainly. But I like to think that what we do is as revolutionary as what they were doing. We're always growing into something new.

What's up next for Boiler Room?

We have had visual people in doing 3D mapping, and that's something we're looking forward to progressing—doing more with the visuals. We've got the upstairs as well, we're starting to do breakfast shows with some high profile DJs, we're going to be doing that regularly. Each will have an individual format. The next step is progressing the US shows, we're alternating weekly between New York and LA, so the next step is to take Boiler Room to America

Breaking Free of the Co-dependency Trap presents a groundbreaking developmental road map to guide readers away from their co-dependent behaviors and toward a life of wholeness and fulfillment.

Breaking Free of the Co-dependency Trap presents a groundbreaking developmental road map to guide readers away from their co-dependent behaviors and toward a life of wholeness and fulfillment.UK Citizens

This is the book that offers a different perspective on codependency and is strongly recommended by Dream Warrior Recovery as part of a solution based recovery. This bestselling book, now in a revised edition, radically challenges the prevailing medical definition of co-dependency as a permanent, progressive, and incurable addiction. Rather, the authors identify it as the result of developmental traumas that interfered with the infant-parent bonding relationship during the first year of life.US Citizens

Drawing on decades of clinical experience, Barry and Janae Weinhold correlate the developmental causes of co-dependency with relationship problems later in life, such as establishing and maintaining boundaries, clinging and dependent behaviors, people pleasing, and difficulty achieving success in the world. Then they focus on healing co-dependency, providing compelling case histories and practical activities to help readers heal early trauma and transform themselves and their primary relationships.

Vintage Ads Most Disturbing Household Products

 

All of the following ads are real and unaltered, so don't blame us. We weren't there when they were made, and in some cases the entire insane thought process that went into creating them has been lost to history. Maybe they made perfect sense at the time?

Maybe. But it's really hard to see how even our parents and grandparents didn't get nightmares from ...

#13. Three-Legged Dingo Boots

vintageadbrowser.com

The Message:

Here are some boots that you should buy, because famous people wear them. Three of them.

The Horror:

Wait, what?

Yes, amazingly, the fact that this ad stars a pre-murder O.J. Simpson is the second-creepiest thing about it. And you can squint and try to read the text all you want -- it makes no reference whatsoever to the fact that their spokesperson has three legs. There's no cute slogan like "Boots so comfortable, you'll wish you had another foot!" Nope. It's like some guy in the art department just said, "Eh, I don't like how you can't really see the chair, let's just add another leg to fill that space."

We know what you're thinking: "Cracked, this is obviously a subtle 'big dick' joke. 'Third leg?' Get it?" But, no, it turns out this was a whole campaign they did with various celebrities, some of whom are women:

eBay
Like, uh ... this famous lady right here.

But O.J. seems to be the most frequent star of the "Third Leg" campaign, which apparently lasted for years. Note how his afro shrinks as he gets more comfortable with his new appendage:

The picture in that third ad would have been perfect for the cover of his book.

Please don't blame us for the inevitable nightmare in which O.J. is running after you, in the dark, those three boots pounding down the pavement after you with a noise like a wounded horse.

#12. Lord West Suits Will Impress Your 7-Year-Old Date

vintageadbrowser.com
"I like my women like I like my code names: 007."

The Message:

Women of all ages dig men in tuxedos!

The Horror:

According to the text, this dinner suit is for "sophisticated traditionalists," a euphemism we weren't previously aware of for "child molesters." Because there's no other way to interpret this picture. That's not tenderness on their faces. That's hunger. If you told us that they're a father and daughter, that would only make it creepier.

And it turns out that this is only the worst example in a whole series of ads associating little girls with selling tuxedos.

eBay
The style is best described as Godfather meets Lolita.

Can you imagine the pitch meeting that led to this campaign? Picture Don Draper from Mad Men standing before his clients, selling them on this idea:

"Class. Elegance. Making out with little girls. These are the values your company represents."

"Did ... did you say 'making out with little girls,' Don?"

"Yes," replied Don with perfect confidence.

"OK, just making sure."

Sitting at the end of the table, Peggy looks at Don and smiles. He did it again.

#11. Man in Tuxedo Carefully Considers Naked Child

library.duke.edu
"Told you it was bigger. Now pay up."

The Message:

Regular soap sinks in the bathtub, causing children to take longer in washing themselves and their fathers to get angry and spank them. Prevent child abuse by buying Ivory Soap -- it floats.

The Horror:

OK, they're clearly just fucking with us at this point. Remove the text and the message becomes clear: "In the old days, child predators used to dress way better than they do now." But let's put the pedophilia overtones aside for the moment and examine the text.

Was the elaborate scenario described under the picture (involving childhoods ruined by non-floating soap) really such a common problem in the '20s, or was this based on the painful personal experiences of whoever commissioned this ad? We're betting on the latter option. Note that the father's body language doesn't say "I'm going to spank you" -- he's clearly pondering which part of the kid's body to break first.

"Maybe the 28th trimester isn't too late for an abortion."

#10. "Are You Sure I'll Still Be a Virgin?"

thesocietypages.org
"If you didn't think band camp counted, I don't see why you'd think this would."

The Message:

Don't worry, teens, you can use Tampax tampons without losing your virginity.

The Horror:

Be honest: How many of you looked at this picture and immediately recognized it as a Tampax ad? And how many looked at it and thought it depicted a teenage girl being sexually propositioned? It's not just us, is it?

This ad would have looked 90 percent less sordid if both people involved were clearly visible. Instead, the second teenager is for some reason sitting on the floor of the porch with her back to us, so we can't see how young, or scared, she is. But, of course, all of that is purely from our own depraved imagination. The real ad is simply about two teenagers debating whether or not inserting a tampon counts as sex.

#9. Escaped Convicts Love Revell Authentic Model Kits

vintageadbrowser.com
"Is this the new plan, boss?"
"I've spent all day plotting against Superman; this is 'Lex Time'."

The Message:

Hey kids! Check out these sweet model kits!

The Horror:

There's only one possible scenario in which this picture could have come to exist: The photographers were getting ready to shoot this ad when they realized that the boy who was supposed to be holding up the models in the picture never showed up for work. Panicking, the man from the ad agency looked around the studio.

"Dmitri, can you come here for a second?" he said to the guy who fixes the lighting. "Stand here and hold this model. Yes, that's great. You'll play the boy in this ad."

"But sir," said the photographer, "Dmitri was just released from jail. In fact, he's still wearing the prison jumpsuit."

"No, no, he's perfect. Look at him. Look at that childlike innocence in his face."

"Could you open the top button maybe, show a little chest hair?"

"Perfect."

#8. Our Competitors = Surgical Ass Torture

vintageadbrowser.com
"Don't worry, sir, the gloves are just to establish atmosphere."

The Message:

Using cheap toilet paper can lead to medical complications.

The Horror:

... which in turn can lead to rubber-gloved hands inserting clamps in your anus. Better play it safe and go with Scott Tissues.

This attempt to traumatize customers into buying their product with threats of anal torture was part of a whole marketing campaign created during the Great Depression in which Scott Tissues' slogan went from "Wipe your butt with us" to "Wipe your butt with us, or die in a world of asshole pain."

Of course, it was all bullshit: There's no such thing as "toilet tissue illness," it was just a thing they made up to convince people to keep buying tissues at a time when they were lucky enough if they had a toilet.

#7. "Before You Scold Me, Mom ... Maybe You'd Better Light Up a Marlboro"

deceptology.com

The Message:

Before you beat your baby for stealing your favorite hat, have a cigarette and relax yourself. Then beat the baby.

The Horror:

How many times did this months-old child have to be punched before it learned to pick up the Marlboros and offer them to mommy to calm her down? If that's not the saddest thing you've imagined all week, you're dead inside. This is actually one in a series of ads from the '50s, back when Marlboro was targeting mommies instead of rugged cowboys. Sometimes the babies actually seem to be guilting their moms into smoking more.

tobacco.stanford.edu
"You turned me into an addict when I was a fetus, now deal with it."

Oddly enough, the version of this ad aimed at fathers doesn't involve scolding, but a pompous baby in a basket defending daddy's rather feminine cigarette tastes (note the reference to "beauty tips" at the bottom).

tobacco.stanford.edu
This is the kind of debate babies have all the time.

Pigs worship God of Materialism

If ever there was a god to prevent you from worshiping material things, it would be this one.

The hideous pig-like thing is the masterpiece by Chinese artist Chen Wenling called God Of Materialism.

Ugly pig with green eye darting at thier master

Looking chuffed, the huge greedy pig has minions of other tiny, and just as unattractive and scary, pigs worshiping in awe at its heels.

The group stare up at their master, adorned with a plethora of jewels and necklaces representing the grotesque love of material things.

The sculpture, which looks like a bad dream, can be found at the Asia Art Centre in Beijing.

And if you're brave enough to go and see it, it will be there till October 18th 2008.

Brad Pitt is reportedly utilising his free time to plan his wedding with Angelina Jolie.

The 48-year-old has taken charge of preparations for the wedding that is expected to take place end of September. He has flown in a team of builders to renovate the home he shares with Jolie in southern France.

"Angelina isn`t so bothered about when they tie the knot, it`s Brad who is piling on the pressure," a website has quoted a source as saying.

"He wants the main house to be finished when the event takes place, even though the close friends and relatives who are invited aren`t the types to care. He wants everything to be absolutely perfect," the source added.

yellow jacket stun gun case for iphone

yellow jacket is a case that transforms the iPhone 4 & 4S into that 650,000-volt stun gun you've always needed.

scheduled to hit the US market in fall 2012 the case is advertised as being able to 
easily stop an aggressive male attacker, and ready for use in less than two seconds. 
its designer seth froom, a former military policeman came up with the product after 
being robbed in his home at gunpoint.

what is the demand for such a hostile product you might ask? well, yellow jacket 
has managed to receive over 100,000 USD worth of backing on the crowd-funding 
website indiegogo which means that there must be quite a few people out there 
who feel the need to transform their phone into a weapon.


detail of the stun gun nodes 

the iPhone's designers could never have conceived half of the the weird and wonderful accessories 
that have been designed for use with the iPhone since its launch, but even in the name of self defense 
a stun gun seems a bit much, doesn't it?

Now You Can Buy a $250,000 Nail Polish

Remember that time when everyone got all freaked out about thatsnakeskin pedicure that cost $300? Well, get ready to completely lose it, because we just got a press release for the “most expensive nail polish in the world.”

That title was previously held by Models Own, which produced a $130,000 bottle (featuring a 24-carat gold, diamond-encrusted lid) back in 2010. However, the self-professed “king of black diamonds,” Azature, has doubled that figure. A bottle of black nail polish containing a whopping 267 carats of black diamonds in the actual polish will go for $250,000. Yikes. You won’t be able to just walk into Duane Reade and buy this sucker, however–only one bottle of the stuff will be produced.

For those of us who can’t afford a quarter of a million dollars for a manicure, Azature is offering a $25 version (see, now doesn’t $25 nail polish sound downright cheap in comparison?) containing one measly black diamond. You’ll be able to pick it up in LA at Fred Segal starting this month.